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But he does remember the acute feeling of triumph when, around age 9, he was finally allowed to cut his hair short. I would ask my mom if I could be someday. After the haircut, strangers finally started perceiving him the way he saw himself, and it felt both right and exciting. The joy was short-lived.

Name: Constantia

Years old: 33
Favourite music: Jazz

We came across Johnny when we were filming for a new BBC Two series Countdown to Life, which looks at how we develop in the womb and how those changes, normal and abnormal, impact us later in life.

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Then, around eight weeks after conception, the sex hormones kick in. His mother has seen the change coming for quite a while.

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The of children aged 10 and under who have been referred to NHS support services to help deal with transgender feelings has more than quadrupled in the last six years, the Victoria Derbyshire programme has learned.

Like the other Guevedoces, Johnny was brought up as a girl because he had no visible testes or penis and what appeared to be a vagina.

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More from the Magazine. Her muscles and chest began growing.

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Johnny lives in a small town in the Dominican Republic where he, and others like him, are known as "Guevedoces", which effectively translates as "penis at twelve". She did lots of studies on the Guevedoces including what must have been rather painful biopsies of their testicles before finally unravelling the mystery of what was going on.

A final interesting observation that Imperato-McGinley made was that these boys, despite being brought up as girls, almost all showed strong heterosexual preferences. My wife, who is a GP, routinely prescribes finasteride as it is an effective way to treat benign enlargement of the prostate, a real curse for many men as they get older.

When Imperato-McGinley investigated the Guevedoces she discovered the reason they don't have male genitalia when they are born is because they are deficient in an enzyme called 5-alpha-reductase, which normally converts testosterone into dihydro-testosterone.

The extraordinary case of the guevedoces

As for Johnny, since he developed male genitalia he has had a of short term girlfriends, but he is still looking for love. This deficiency seems to be a genetic condition, quite common in this part of the Dominican Republic, but vanishingly rare elsewhere. When you are conceived you normally have a pair of X chromosomes if you are to become a girl and a set of XY chromosomes if you are destined to be male.

For the first weeks of life in womb you are neither, though in both sexes nipples start to grow.

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Image source, Science Photo Library. Here is the story of two of the youngest transgender children in the UK - with permission from their parents and with the support of the children's schools.

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Girl or boy, it makes no difference. At puberty, like other boys, they get a second surge of testosterone. Johnny, once known as Felicita, remembers going to school in a little red dress, though he says he was never happy doing girl things.

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So the boys, despite having an XY chromosome, appear female when they are born. The story of two transgender children.

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In the s she made her way to this remote part of the Dominican Republic, drawn by extraordinary reports of girls turning into boys. She concluded in her seminal paper that hormones in the womb matter more than rearing when it comes to your sexual orientation.

Transgender stories: 'people think we wake up and decide to be trans'

This time the body does respond and they sprout muscles, testes and a penis. Finasteride is also used to treat male pattern baldness. You could see she was going to be a boy.

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Dominican Republic. This is still a controversial topic and one I explore later in the film when I meet Mati, who decided from the earliest age that though "he" looked like a boy, Mati was really a girl. When he became obviously male he was taunted at school, and responded with his fists. Find out more.

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I love her however she is. The discovery of a small community in the Dominican Republic, where some males are born looking like girls and only grow penises at puberty, has led to the development of a blockbuster drug that has helped millions of people, writes Michael Mosley. Another thing that Imperato-McGinley discovered, which would have profound implications for many men around the world, was that the Guevedoces tend to have small prostates.

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We also filmed with Carla, who at the age of seven is on the brink of changing into Carlos. It is only when he approached puberty that his penis grew and testicles descended. If you're female and you don't make dihydro-testosterone then your tubercle becomes a clitoris.

Gender bender

Imperato-McGinley's thorough medical investigations showed that in most cases their new, male equipment seems to work fine and that most Guevedoces live out their lives as men, though some go through an operation and remain female. So why does it happen? He thought this was extremely interesting and set in progress research which led to the development of what has become a best-selling drug, finasteride, which blocks the action of 5-alpha-reductase, mimicking the lack of dihydro-testosterone seen in the Guevedoces.

Related Topics. This observation, made inwas picked up by Roy Vagelos, head of research at the multinational pharmaceutical giant, Merck.

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When she got there she found the rumours were true. If you're genetically male the Y chromosome instructs your gon to become testicles and sends testosterone to a structure called the tubercle, where it is converted into a more potent hormone called dihydro-testosterone This in turn transforms the tubercle into a penis.

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